2017

Richard-Carpentier G, Sauvageau G.  Bringing a Leukemic Stem Cell Gene Signature into Clinics: Are We There Yet?   Cell Stem Cell. 2017 Mar 2;20(3):300-301. doi: 10.1016/j.stem.2017.02.010.

Baccelli I, Krosl J, Boucher G, Boivin I, Lavallée VP, Hébert J, Lemieux S, Marinier A, Sauvageau G. A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens.  Blood Cancer J. 2017 Feb 17;7(2):e529. doi: 10.1038/bcj.2017.10.

2016

Maiga A, Lemieux S, Pabst C, Lavallée VP, Bouvier M, Sauvageau G, Hébert J. (2016). Transcriptome analysis of G protein-coupled receptors in distinct genetic subgroups of acute myeloid leukemia: identification of potential disease-specific targets. Blood Cancer J. 2016 Jun 3;6(6):e431. doi: 10.1038/bcj.2016.36.

Lavallée VP, Krosl J, Lemieux S, Boucher G, Gendron P, Pabst C, Boivin I, Marinier A, Guidos CJ, Meloche S, Hébert J, Sauvageau G. (2016). Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors. Blood. 2016 Jun 16;127(24):3054-61. doi: 10.1182/blood-2016-03-705053. Epub 2016 Mar 31.

Lavallée VP, Lemieux S, Boucher G, Gendron P, Boivin I, Armstrong RN, Sauvageau G, Hébert J. (2016). RNA-sequencing analysis of core binding factor AML identifies recurrent ZBTB7A mutations and defines RUNX1-CBFA2T3 fusion signature. Blood. 2016 May 19;127(20):2498-501. doi: 10.1182/blood-2016-03-703868. Epub 2016 Mar 11.

Lavallée VP, Lemieux S, Boucher G, Gendron P, Boivin I, Girard S, Hébert J, Sauvageau G. (2016). Identification of MYC mutations in acute myeloid leukemias with NUP98-NSD1 translocations Leukemia. Leukemia. 2016 Feb 9. doi: 10.1038/leu.2016.19.

Pabst C, Bergeron A, Lavallée VP, Yeh J, Gendron P, Norddahl GL, Krosl J, Boivin I, Deneault E, Simard J, Imren S, Boucher G, Eppert K, Herold T, Bohlander SK, Humphries K, Lemieux S, Hébert J, Sauvageau G, Barabé F. (2016). GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo. Blood. 2016 Apr 21;127(16):2018-27. doi: 10.1182/blood-2015-11-683649. Epub 2016 Feb 1.

Shifman AR, Johnson RM, Wilhelm BT. (2016). Cascade: an RNA-seq visualization tool for cancer genomics. BMC Genomics. 2016 Jan 25;17(1):75. doi: 10.1186/s12864-016-2389-8.

2015

Kleiderman E, Avard D, Besso A, Ali-Khan S, Sauvageau G, Hébert J (2015). Disclosure of incidental findings in cancer genomic research: investigators’ perceptions on obligations and barriers. Clin. Genet. 88(4): 320-6.

Lavallée VP, Baccelli I, Krosl J, Wilhelm B, Barabé F, Gendron P, Boucher G, Lemieux S, Marinier A, Meloche S, Hébert J, Sauvageau G (2015). The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias. Nat. Genet. 47:1032-1037.

Lavallé VP, Gendron P, Lemieux S, D’Angelo G, Hébert J, Sauvageau G. (2015). EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations. Blood. 125(1): 140-3.

2014

Lehnertz B, Pabst C, Su L, Miller M, Liu F, Yi L, Zhang RG, Krosl J, Yung E, Kirschner J, Rosten P, Underhill TM, Jin J, Hébert J, Sauvageau G, Humphries RK, Rossi FM. (2014). The methyltransferase G9a regulates HoxA9-dependent transcription in AML. Genes Dev. 28(4): 317-27.

Pabst C, Krosl J, Fares I, Boucher G, Ruel R, Marinier A, Lemieux S, Hébert J, Sauvageau G. (2014). Identification of small molecules that support human leukemia stem cell activity ex vivo. Nat. Methods. 11(4): 436-42.

Lavallée VP, Boivin I, Armstrong RN, Lemieux S, Hébert J, Sauvageau G. (2014, June). AML with EVI1 Rearrangements Are Characterized By Frequent SF3B1 And IKZF1 Mutations. 19th Congress of European Hematology Association (EHA), Milan, Italy. Published in Haematologica. 99(supp 1): 13.

Lavallée VP, Boivin I, Armstrong RN, Lemieux S, Gendron P, Hébert J, Sauvageau G. (2014, Aug). AML with EVI1 rearrangements are characterized by SF3B1 and IKZF1 mutations and distinct expression of MECOM isoforms. 43rd Annual Scientific Meeting of the International Society for Experimental Hematology (ISEH), Montreal, Canada. Published in Exp. Hematol. 42(8): S44.

Lehnertz B, Boucher G, Mallard W, Gendron P, Hébert J, Lemieux S, Rinn J, Sauvageau G. (2014, Aug). Long non-coding RNA expression in normal and leukemic human blood samples: Towards the identification of novel biomarkers and hematopoietic regulators. 43rd Annual Scientific Meeting of the International Society for Experimental Hematology (ISEH), Montreal, Canada. Published in Exp. Hematol. 42(8): S44.

Celton M, Forest A, Gosse G, Lemieux S, Hébert J, Sauvageau G, Wilhelm BT. (2014). Epigenetic regulation of GATA2 and its impact on normal karyotype acute myeloid leukemia. Leukemia. 28(8): 1617-26.

2013

Macrae T, Sargeant T, Lemieux S, Hébert J, Deneault E, Sauvageau G. (2013). RNA-Seq Reveals Spliceosome and Proteasome Genes as Most Consistent Transcripts in Human Cancer Cells. PLoS One 8(9):e72884.

Lavallée VP, Gendron P, Boucher G, Arteau M, Wilhelm BT, Lemieux S, Hébert J, Sauvageau G. (2013, Nov). NGS-Based Detection Of Multiple RAS-Mutated Clones In MLL-Rearranged Leukemias Suggests Strong Oncogenic Collaboration. 55th Annual Meeting of the American Society of Hematology (ASH), New Orleans, USA. Published in Blood. 122(21): 744.

Sauvageau G, Pabst C, Lemieux S, Hébert J, Krosl J. (2013, Nov). Novel Targeting Strategies for Leukemia-Initiating Cells in Myeloid Neoplasms. 55th Annual Meeting of the American Society of Hematology (ASH), New Orleans, USA. Published in Blood. 122(21): SCI-27.

Black L, Avard D, Zawati MH, Knoppers BM, Hébert J, Sauvageau G. (2013). Funding considerations for the disclosure of genetic incidental findings in biobank research. Clin. Genet. 84(5):397-406.

2012

Simon C, Chagraoui J, Krosl J, Gendron P, Wilhelm B, Lemieux S, Boucher G, Chagnon P, Drouin S, Lambert R, Rondeau C, Bilodeau A, Lavallée S, Sauvageau M, Hébert J, Sauvageau G. (2012). A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia. Genes Dev. 26:651-6.